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6MAC

Ternary structure of GDF11 bound to ActRIIB-ECD and Alk5-ECD

Summary for 6MAC
Entry DOI10.2210/pdb6mac/pdb
DescriptorGrowth/differentiation factor 11, Activin receptor type-2B, TGF-beta receptor type-1, ... (5 entities in total)
Functional Keywordsgrowth factor, receptor, tgfb, signaling, signaling protein
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains3
Total formula weight32901.17
Authors
Goebel, E.J.,Thompson, T.B. (deposition date: 2018-08-27, release date: 2019-07-17, Last modification date: 2023-10-11)
Primary citationGoebel, E.J.,Corpina, R.A.,Hinck, C.S.,Czepnik, M.,Castonguay, R.,Grenha, R.,Boisvert, A.,Miklossy, G.,Fullerton, P.T.,Matzuk, M.M.,Idone, V.J.,Economides, A.N.,Kumar, R.,Hinck, A.P.,Thompson, T.B.
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
Proc.Natl.Acad.Sci.USA, 116:15505-15513, 2019
Cited by
PubMed: 31315975
DOI: 10.1073/pnas.1906253116
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.34 Å)
Structure validation

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