6LP8
Crystal structure of human DHODH in complex with inhibitor 1243
Summary for 6LP8
Entry DOI | 10.2210/pdb6lp8/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (9 entities in total) |
Functional Keywords | dhodh, inhibitor, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 41553.91 |
Authors | |
Primary citation | Zuo, Z.,Liu, X.,Qian, X.,Zeng, T.,Sang, N.,Liu, H.,Zhou, Y.,Tao, L.,Zhou, X.,Su, N.,Yu, Y.,Chen, Q.,Luo, Y.,Zhao, Y. Bifunctional Naphtho[2,3- d ][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production. J.Med.Chem., 63:7633-7652, 2020 Cited by PubMed: 32496056DOI: 10.1021/acs.jmedchem.0c00512 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.79 Å) |
Structure validation
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