6KIZ

Cryo-EM structure of human MLL1-NCP complex, binding mode2

Summary for 6KIZ

• Entry DOI: 10.2210/pdb6kiz/pdb
• EMDB information: 0695
• Descriptor: Histone H3, Set1/Ash2 histone methyltransferase complex subunit ASH2, S-ADENOSYL-L-HOMOCYSTEINE, ... (12 entities in total)
• Functional Keywords: histone modification, nucleosome, mll, transcription, transcription-dna complex, transcription/dna
• Biological source: Xenopus laevis (African clawed frog); More
• Total number of polymer chains: 14
• Total formula weight: 379170.28

Authors

Huang, J.,Xue, H.,Yao, T. (deposition date: 2019-07-20, release date: 2019-09-11, Last modification date: 2024-03-27)

• Primary citation: Xue, H.,Yao, T.,Cao, M.,Zhu, G.,Li, Y.,Yuan, G.,Chen, Y.,Lei, M.,Huang, J.; Structural basis of nucleosome recognition and modification by MLL methyltransferases.; Nature, 573:445-449, 2019; PubMed: 31485071; DOI: 10.1038/s41586-019-1528-1

Experimental method

ELECTRON MICROSCOPY (4.5 Å)