6K72

eIF2(aP) - eIF2B complex

Replaces:  6JLX

Summary for 6K72

EMDB information9841
DescriptorTranslation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, Translation initiation factor eIF-2B subunit gamma, ... (8 entities in total)
Functional Keywordstranslation initiation, translation
Biological sourceHomo sapiens (Human)
Total number of polymer chains14
Total molecular weight684364.65
Authors
Kashiwagi, K.,Yokoyama, T.,Ito, T. (deposition date: 2019-06-05, release date: 2019-07-10)
Primary citation
Kashiwagi, K.,Yokoyama, T.,Nishimoto, M.,Takahashi, M.,Sakamoto, A.,Yonemochi, M.,Shirouzu, M.,Ito, T.
Structural basis for eIF2B inhibition in integrated stress response.
Science, 364:495-499, 2019
PubMed: 31048492 (PDB entries with the same primary citation)
DOI: 10.1126/science.aaw4104
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY
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Structure validation

ClashscoreRamachandran outliersSidechain outliers10 0.1% 1.7%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures