6JWE

structure of RET G-quadruplex in complex with colchicine

Summary for 6JWE

• Entry DOI: 10.2210/pdb6jwe/pdb
• Related: 2L88
• Descriptor: DNA (5'-D(*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*CP*GP*GP*GP*GP*T)-3'), N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[d]heptalen-7-yl]ethanamide (2 entities in total)
• Functional Keywords: ret, g-quadruplex, colchicine, dna
• Biological source: Homo sapiens
• Total number of polymer chains: 1
• Total formula weight: 6793.51

Authors

Wang, F.,Wang, C.,Liu, Y.,Lan, W.X.,Li, Y.M.,Wang, R.X.,Cao, C. (deposition date: 2019-04-20, release date: 2020-02-26, Last modification date: 2023-06-14)

• Primary citation: Wang, F.,Wang, C.,Liu, Y.,Lan, W.,Han, H.,Wang, R.,Huang, S.,Cao, C.; Colchicine selective interaction with oncogene RET G-quadruplex revealed by NMR.; Chem.Commun.(Camb.), 56:2099-2102, 2020; PubMed: 32025680; DOI: 10.1039/d0cc00221f

Experimental method

SOLUTION NMR