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6JN3

Serine Beta-Lactamase KPC-2 in Complex with Dual MBL/SBL Inhibitor MS05

Summary for 6JN3
Entry DOI10.2210/pdb6jn3/pdb
DescriptorSerine Beta-Lactamase KPC-2, [(1R)-1-[[(2S)-2-methyl-3-sulfanyl-propanoyl]amino]-2-phenyl-ethyl]boronic acid, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywordsbeta-lactamase, serine-beta-lactamase kpc-2, kpc-2, carbapenemase, hydrolase
Biological sourceKlebsiella pneumoniae
Total number of polymer chains4
Total formula weight114444.03
Authors
Li, G.-B.,Liu, S. (deposition date: 2019-03-13, release date: 2019-07-17, Last modification date: 2023-11-22)
Primary citationWang, Y.L.,Liu, S.,Yu, Z.J.,Lei, Y.,Huang, M.Y.,Yan, Y.H.,Ma, Q.,Zheng, Y.,Deng, H.,Sun, Y.,Wu, C.,Yu, Y.,Chen, Q.,Wang, Z.,Wu, Y.,Li, G.B.
Structure-Based Development of (1-(3'-Mercaptopropanamido)methyl)boronic Acid Derived Broad-Spectrum, Dual-Action Inhibitors of Metallo- and Serine-beta-lactamases.
J.Med.Chem., 62:7160-7184, 2019
Cited by
PubMed: 31269398
DOI: 10.1021/acs.jmedchem.9b00735
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.216 Å)
Structure validation

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