6J71

HuA21-scFv in complex with the extracellular domain(ECD) of HER2

Summary for 6J71

• Entry DOI: 10.2210/pdb6j71/pdb
• Descriptor: Receptor tyrosine-protein kinase erbB-2, anti-HER2 humanized antibody HuA21, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: tyrosine-protein kinase, antibody, transcription regulation, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 95889.77

Authors

Wang, Z.,Guo, G.,Cheng, B.,Zhu, Z.,Niu, L.,Zhang, H. (deposition date: 2019-01-16, release date: 2019-02-27, Last modification date: 2023-11-22)

• Primary citation: Wang, Z.,Cheng, L.,Guo, G.,Cheng, B.,Hu, S.,Zhang, H.,Zhu, Z.,Niu, L.; Structural insight into a matured humanized monoclonal antibody HuA21 against HER2-overexpressing cancer cells.; Acta Crystallogr D Struct Biol, 75:554-563, 2019; PubMed: 31205018; DOI: 10.1107/S2059798319006995

Experimental method

X-RAY DIFFRACTION (2.918 Å)