6J5L

Crystal structure of Trk-A in complex with the Pan-Trk Kinase Inhibitor, compound 10e

Summary for 6J5L

Entry DOI	10.2210/pdb6j5l/pdb
Descriptor	High affinity nerve growth factor receptor, N-{2-[({3-[6-(piperazin-1-yl)pyridin-3-yl]-1H-indazol-5-yl}amino)methyl]phenyl}methanesulfonamide (3 entities in total)
Functional Keywords	transferase inhibitor, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34739.19
Authors	Kensuke, A.,Kazutaka, I. (deposition date: 2019-01-11, release date: 2019-07-17, Last modification date: 2023-11-22)
Primary citation	Shirahashi, H.,Toriihara, E.,Suenaga, Y.,Yoshida, H.,Akaogi, K.,Endou, Y.,Wakabayashi, M.,Takashima, M. The discovery of novel 3-aryl-indazole derivatives as peripherally restricted pan-Trk inhibitors for the treatment of pain. Bioorg.Med.Chem.Lett., 29:2320-2326, 2019 Cited by PubMed: 31235262 DOI: 10.1016/j.bmcl.2019.06.018 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation