6IZZ

The RNA-dependent RNA polymerase domain of dengue 3 NS5, bound with RK-0404678

Summary for 6IZZ

Entry DOI	10.2210/pdb6izz/pdb
Descriptor	Genome polyprotein, ZINC ION, 2-oxo-2H-1,3-benzoxathiol-5-yl acetate, ... (4 entities in total)
Functional Keywords	dengue, ns5, rna-dependent rna polymerase, viral protein
Biological source	Dengue virus 3
Total number of polymer chains	1
Total formula weight	75140.02
Authors	Shimizu, H.,Sekine, S. (deposition date: 2018-12-20, release date: 2019-12-25, Last modification date: 2023-11-22)
Primary citation	Shimizu, H.,Saito, A.,Mikuni, J.,Nakayama, E.E.,Koyama, H.,Honma, T.,Shirouzu, M.,Sekine, S.I.,Shioda, T. Discovery of a small molecule inhibitor targeting dengue virus NS5 RNA-dependent RNA polymerase. Plos Negl Trop Dis, 13:e0007894-e0007894, 2019 Cited by PubMed: 31738758 DOI: 10.1371/journal.pntd.0007894 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.97 Å)

Structure validation