6IQ5

Crystal Structure of CYP1B1 and Inhibitor Having Azide Group

Summary for 6IQ5

Entry DOI	10.2210/pdb6iq5/pdb
Descriptor	Cytochrome P450 1B1, PROTOPORPHYRIN IX CONTAINING FE, 2-(cis-4-azidocyclohexyl)-4H-naphtho[1,2-b]pyran-4-one, ... (4 entities in total)
Functional Keywords	cytochrome p450, inhibitor, cyp1b1, azide, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	106085.57
Authors	Kubo, M.,Yamamoto, K.,Itoh, T. (deposition date: 2018-11-06, release date: 2019-01-30, Last modification date: 2024-03-27)
Primary citation	Kubo, M.,Yamamoto, K.,Itoh, T. Design and synthesis of selective CYP1B1 inhibitor via dearomatization of alpha-naphthoflavone. Bioorg. Med. Chem., 27:285-304, 2019 Cited by PubMed: 30553624 DOI: 10.1016/j.bmc.2018.11.045 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.7 Å)

Structure validation