6ILZ
Crystal structure of PKCiota in complex with inhibitor
Summary for 6ILZ
| Entry DOI | 10.2210/pdb6ilz/pdb |
| Descriptor | Protein kinase C iota type, 2-amino-5-[3-(piperazin-1-yl)phenyl]-N-(pyridin-4-yl)pyridine-3-carboxamide (2 entities in total) |
| Functional Keywords | kinase, atypical kinase, phosphorylation, inhibitor, pkciota, iota type, kinase domain, transferase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 4 |
| Total formula weight | 160917.04 |
| Authors | Baburajendran, N.,Hill, J. (deposition date: 2018-10-21, release date: 2019-06-26, Last modification date: 2023-11-22) |
| Primary citation | Kwiatkowski, J.,Baburajendran, N.,Poulsen, A.,Liu, B.,Tee, D.H.Y.,Wong, Y.X.,Poh, Z.Y.,Ong, E.H.,Dinie, N.,Cherian, J.,Jansson, A.E.,Hill, J.,Keller, T.H.,Hung, A.W. Fragment-based Discovery of a Small-Molecule Protein Kinase C-iota Inhibitor Binding Post-kinase Domain Residues. Acs Med.Chem.Lett., 10:318-323, 2019 Cited by PubMed: 30891133DOI: 10.1021/acsmedchemlett.8b00546 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.261 Å) |
Structure validation
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