7EMN

The atomic structure of SHP2 E76A mutant

Replaces:  6IHZ

Summary for 7EMN

• Entry DOI: 10.2210/pdb7emn/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 11 (2 entities in total)
• Functional Keywords: phosphatase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 122780.52

Authors

Luo, F.,Xie, J.J.,Zhu, J.D.,Liu, C. (deposition date: 2021-04-14, release date: 2021-05-05, Last modification date: 2023-11-29)

• Primary citation: Tao, Y.,Xie, J.,Zhong, Q.,Wang, Y.,Zhang, S.,Luo, F.,Wen, F.,Xie, J.,Zhao, J.,Sun, X.,Long, H.,Ma, J.,Zhang, Q.,Long, J.,Fang, X.,Lu, Y.,Li, D.,Li, M.,Zhu, J.,Sun, B.,Li, G.,Diao, J.,Liu, C.; A novel partially open state of SHP2 points to a "multiple gear" regulation mechanism.; J.Biol.Chem., 296:100538-100538, 2021; PubMed: 33722610; DOI: 10.1016/j.jbc.2021.100538

Experimental method

X-RAY DIFFRACTION (3 Å)