Crystal structure of the Vibrio cholera VqmA-Ligand-DNA complex provides molecular mechanisms for drug design

Summary for 6IDE

DescriptorTranscriptional regulator LuxR family, DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*AP*AP*TP*CP*CP*CP*CP*CP*CP*T)-3'), DNA (5'-D(*AP*GP*GP*GP*GP*GP*GP*AP*TP*TP*TP*CP*CP*CP*CP*CP*CP*T)-3'), ... (5 entities in total)
Functional Keywordsvibrio cholera, quorum sensing, transcription regulator, transcription-dna complex, transcription/dna
Biological sourceVibrio cholerae
Total number of polymer chains4
Total molecular weight69019.68
Wu, H.,Li, M.J.,Guo, H.J.,Zhou, H.,Li, B.,Xu, Q.,Xu, C.Y.,Yu, F.,He, J.H. (deposition date: 2018-09-09, release date: 2019-01-16)
Primary citation
Wu, H.,Li, M.,Guo, H.,Zhou, H.,Li, B.,Xu, Q.,Xu, C.,Yu, F.,He, J.
Crystal structure of theVibrio choleraeVqmA-ligand-DNA complex provides insight into ligand-binding mechanisms relevant for drug design
J. Biol. Chem., 2019
PubMed: 30610119 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.RA118.006082
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2305 0.2% 3.1% 4.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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