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6I8Y

Crystal structure of Spindlin1 in complex with the Methyltransferase inhibitor A366

Summary for 6I8Y
Entry DOI10.2210/pdb6i8y/pdb
DescriptorSpindlin-1, 5'-methoxy-6'-[3-(pyrrolidin-1-yl)propoxy]spiro[cyclobutane-1,3'-indol]-2'-amine, 1,2-ETHANEDIOL, ... (8 entities in total)
Functional Keywordsepigenetics, tudor domain, methyl-lysine, methyl-arginine, gene regulation
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight26594.18
Authors
Primary citationFagan, V.,Johansson, C.,Gileadi, C.,Monteiro, O.,Dunford, J.E.,Nibhani, R.,Philpott, M.,Malzahn, J.,Wells, G.,Faram, R.,Cribbs, A.P.,Halidi, N.,Li, F.,Chau, I.,Greschik, H.,Velupillai, S.,Allali-Hassani, A.,Bennett, J.,Christott, T.,Giroud, C.,Lewis, A.M.,Huber, K.V.M.,Athanasou, N.,Bountra, C.,Jung, M.,Schule, R.,Vedadi, M.,Arrowsmith, C.,Xiong, Y.,Jin, J.,Fedorov, O.,Farnie, G.,Brennan, P.E.,Oppermann, U.
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function.
J.Med.Chem., 62:9008-9025, 2019
Cited by
PubMed: 31550156
DOI: 10.1021/acs.jmedchem.9b00562
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.52 Å)
Structure validation

217705

数据于2024-03-27公开中

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