6I6Z

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH

Replaces:  4UEF

Summary for 6I6Z

• Entry DOI: 10.2210/pdb6i6z/pdb
• Descriptor: Carboxypeptidase A1, (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, ZINC ION, ... (4 entities in total)
• Functional Keywords: protease, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 70195.12

Authors

Gallego, P.,Reverter, D. (deposition date: 2018-11-15, release date: 2018-12-12, Last modification date: 2024-01-24)

• Primary citation: Covaleda, G.,Gallego, P.,Vendrell, J.,Georgiadis, D.,Lorenzo, J.,Dive, V.,Aviles, F.X.,Reverter, D.,Devel, L.; Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes.; J. Med. Chem., 62:1917-1931, 2019; PubMed: 30688452; DOI: 10.1021/acs.jmedchem.8b01465

Experimental method

X-RAY DIFFRACTION (1.72 Å)