6I4N

Dodecamer DNA containing the synthetic base pair P-Z in complex with a pyrrole-imidazole polyamide

6I4N の概要

• エントリーDOI: 10.2210/pdb6i4n/pdb
• 分子名称: DNA (5'-D(*CP*GP*AP*TP*(DP)P*TP*AP*(DZ)P*AP*TP*CP*G)-3'), 3-[3-[[4-[[4-[[4-[[4-[[(2~{R})-2-azaniumyl-4-[[1-methyl-4-[[1-methyl-4-[[1-methyl-4-[(1-methylimidazol-2-yl)carbonylamino]pyrrol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]pyrrol-2-yl]carbonylamino]butanoyl]amino]-1-methyl-imidazol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]-1-methyl-pyrrol-2-yl]carbonylamino]propanoylamino]propyl-dimethyl-azanium (2 entities in total)
• 機能のキーワード: dna, synthetic base pair, z, p, pyrrole-imidazole polyamide
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 8652.18

構造登録者

Padroni, G.,Parkison, J.,Burley, G.A. (登録日: 2018-11-10, 公開日: 2019-06-12, 最終更新日: 2019-07-10)

• 主引用文献: Padroni, G.,Withers, J.M.,Taladriz-Sender, A.,Reichenbach, L.F.,Parkinson, J.A.,Burley, G.A.; Sequence-Selective Minor Groove Recognition of a DNA Duplex Containing Synthetic Genetic Components.; J.Am.Chem.Soc., 141:9555-9563, 2019; PubMed: 31117639; DOI: 10.1021/jacs.8b12444

実験手法

SOLUTION NMR