8AYH

Structure of Complement C5 in Complex with small molecule inhibitor and CVF

Replaces:  6I2X

Summary for 8AYH

• Entry DOI: 10.2210/pdb8ayh/pdb
• EMDB information: 15713
• Descriptor: Complement C5 beta chain, Complement C5 alpha chain, Cobra venom factor, ... (5 entities in total)
• Functional Keywords: inhibitor, protease, complex, cryo-em, toxin, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 371446.33

Authors

Srinivas, H. (deposition date: 2022-09-02, release date: 2022-12-21)

• Primary citation: Jendza, K.,Kato, M.,Salcius, M.,Srinivas, H.,De Erkenez, A.,Nguyen, A.,McLaughlin, D.,Be, C.,Wiesmann, C.,Murphy, J.,Bolduc, P.,Mogi, M.,Duca, J.,Namil, A.,Capparelli, M.,Darsigny, V.,Meredith, E.,Tichkule, R.,Ferrara, L.,Heyder, J.,Liu, F.,Horton, P.A.,Romanowski, M.J.,Schirle, M.,Mainolfi, N.,Anderson, K.,Michaud, G.A.; A small-molecule inhibitor of C5 complement protein.; Nat.Chem.Biol., 15:666-668, 2019; PubMed: 31209353; DOI: 10.1038/s41589-019-0303-9

Experimental method

ELECTRON MICROSCOPY (3.35 Å)