6I1L

Crystal structure of FnCas12a in complex with a crRNA guide and ssDNA target

Summary for 6I1L

Entry DOI	10.2210/pdb6i1l/pdb
Descriptor	CRISPR-associated endonuclease Cas12a, crRNA (40-MER), ssDNA target strand, ... (7 entities in total)
Functional Keywords	crispr-cas12a, fncas12a, crispr-cpf1, fncpf1, hydrolase
Biological source	Francisella tularensis subsp. novicida (strain U112) More
Total number of polymer chains	6
Total formula weight	344862.56
Authors	Jinek, M.,Swarts, D.C. (deposition date: 2018-10-29, release date: 2019-01-23, Last modification date: 2024-01-24)
Primary citation	Swarts, D.C.,Jinek, M. Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a. Mol. Cell, 73:589-600.e4, 2019 Cited by PubMed: 30639240 DOI: 10.1016/j.molcel.2018.11.021 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.98 Å)

Structure validation