6I1K
Crystal structure of catalytically inactive FnCas12a in complex with a crRNA guide and a dsDNA target
Summary for 6I1K
Entry DOI | 10.2210/pdb6i1k/pdb |
Descriptor | CRISPR-associated endonuclease Cas12a, crRNA (40-MER), DNA target strand (38-MER), ... (7 entities in total) |
Functional Keywords | crispr-cas12a, fncas12a, crispr-cpf1, fncpf1, hydrolase |
Biological source | Francisella tularensis subsp. novicida (strain U112) More |
Total number of polymer chains | 4 |
Total formula weight | 189457.09 |
Authors | Jinek, M.,Swarts, D.C. (deposition date: 2018-10-29, release date: 2019-01-23, Last modification date: 2024-01-24) |
Primary citation | Swarts, D.C.,Jinek, M. Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a. Mol. Cell, 73:589-600.e4, 2019 Cited by PubMed: 30639240DOI: 10.1016/j.molcel.2018.11.021 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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