6HYG

Heteromeric tandem IgG4/IgG1 Fc

Summary for 6HYG

• Entry DOI: 10.2210/pdb6hyg/pdb
• Descriptor: IgHG1 and IgHG4 hybrid, ZINC ION (3 entities in total)
• Functional Keywords: immunoglobulin, fc, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 53648.42

Authors

Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G. (deposition date: 2018-10-21, release date: 2019-03-13, Last modification date: 2024-01-24)

• Primary citation: Casaletto, J.B.,Geddie, M.L.,Abu-Yousif, A.O.,Masson, K.,Fulgham, A.,Boudot, A.,Maiwald, T.,Kearns, J.D.,Kohli, N.,Su, S.,Razlog, M.,Raue, A.,Kalra, A.,Hakansson, M.,Logan, D.T.,Welin, M.,Chattopadhyay, S.,Harms, B.D.,Nielsen, U.B.,Schoeberl, B.,Lugovskoy, A.A.,MacBeath, G.; MM-131, a bispecific anti-Met/EpCAM mAb, inhibits HGF-dependent and HGF-independent Met signaling through concurrent binding to EpCAM.; Proc.Natl.Acad.Sci.USA, 116:7533-7542, 2019; PubMed: 30898885; DOI: 10.1073/pnas.1819085116

Experimental method

X-RAY DIFFRACTION (2.31 Å)