6HR2

Crystal structure of PROTAC 2 in complex with the bromodomain of human SMARCA4 and pVHL:ElonginC:ElonginB

Summary for 6HR2

• Entry DOI: 10.2210/pdb6hr2/pdb
• Related: 6HAX 6HAY 6HAZ
• Descriptor: Transcription activator BRG1, von Hippel-Lindau disease tumor suppressor, Elongin-C, ... (8 entities in total)
• Functional Keywords: bromodomain, brg1, smarca4, protac, vhl, ternary complex, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 110472.79

Authors

Roy, M.,Bader, G.,Diers, E.,Trainor, N.,Farnaby, W.,Ciulli, A. (deposition date: 2018-09-26, release date: 2019-06-12, Last modification date: 2019-07-03)

• Primary citation: Farnaby, W.,Koegl, M.,Roy, M.J.,Whitworth, C.,Diers, E.,Trainor, N.,Zollman, D.,Steurer, S.,Karolyi-Oezguer, J.,Riedmueller, C.,Gmaschitz, T.,Wachter, J.,Dank, C.,Galant, M.,Sharps, B.,Rumpel, K.,Traxler, E.,Gerstberger, T.,Schnitzer, R.,Petermann, O.,Greb, P.,Weinstabl, H.,Bader, G.,Zoephel, A.,Weiss-Puxbaum, A.,Ehrenhofer-Wolfer, K.,Wohrle, S.,Boehmelt, G.,Rinnenthal, J.,Arnhof, H.,Wiechens, N.,Wu, M.Y.,Owen-Hughes, T.,Ettmayer, P.,Pearson, M.,McConnell, D.B.,Ciulli, A.; BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design.; Nat.Chem.Biol., 15:672-680, 2019; PubMed: 31178587; DOI: 10.1038/s41589-019-0294-6

Experimental method

X-RAY DIFFRACTION (1.76 Å)