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6HOY

Human Sirt6 in complex with ADP-ribose and the inhibitor trichostatin A

Summary for 6HOY
Entry DOI10.2210/pdb6hoy/pdb
DescriptorNAD-dependent protein deacetylase sirtuin-6, [(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL [HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL] HYDROGEN PHOSPHATE, ZINC ION, ... (8 entities in total)
Functional Keywordsdeacylase, inhibitor, hydroxamate, non-competitive, isoform-selective, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight70364.47
Authors
You, W.,Steegborn, C. (deposition date: 2018-09-18, release date: 2018-11-14, Last modification date: 2024-01-24)
Primary citationYou, W.,Steegborn, C.
Structural Basis of Sirtuin 6 Inhibition by the Hydroxamate Trichostatin A: Implications for Protein Deacylase Drug Development.
J.Med.Chem., 61:10922-10928, 2018
Cited by
PubMed: 30395713
DOI: 10.1021/acs.jmedchem.8b01455
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.7 Å)
Structure validation

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