6HLL

Crystal structure of the Neurokinin 1 receptor in complex with the small molecule antagonist CP-99,994

Summary for 6HLL

Entry DOI	10.2210/pdb6hll/pdb
Descriptor	Substance-P receptor,GlgA glycogen synthase,Substance-P receptor, (2~{S},3~{S})-~{N}-[(2-methoxyphenyl)methyl]-2-phenyl-piperidin-3-amine (2 entities in total)
Functional Keywords	7-tm; gpcr; signalling protein, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	1
Total formula weight	59330.47
Authors	Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. (deposition date: 2018-09-11, release date: 2019-01-16, Last modification date: 2024-01-24)
Primary citation	Schoppe, J.,Ehrenmann, J.,Klenk, C.,Rucktooa, P.,Schutz, M.,Dore, A.S.,Pluckthun, A. Crystal structures of the human neurokinin 1 receptor in complex with clinically used antagonists. Nat Commun, 10:17-17, 2019 Cited by PubMed: 30604743 DOI: 10.1038/s41467-018-07939-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.27 Å)

Structure validation