X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)3-Lys]-Lys-4-Amba

Summary for 6HLD

DescriptorFurin, ALN-ARG-ARG-ARG-SLL-LYS-00S, CALCIUM ION, ... (8 entities in total)
Functional Keywordsprotease proprotein convertase inhibitor complex cyclic peptide, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight54056.77
Dahms, S.O. (deposition date: 2018-09-11, release date: 2019-02-06)
Primary citation
Lam van, T.V.,Ivanova, T.,Hardes, K.,Heindl, M.R.,Morty, R.E.,Bottcher-Friebertshauser, E.,Lindberg, I.,Than, M.E.,Dahms, S.O.,Steinmetzer, T.
Design, synthesis and characterization of new macrocyclic inhibitors of the proprotein convertase furin.
ChemMedChem, 2019
PubMed: 30680958 (PDB entries with the same primary citation)
DOI: 10.1002/cmdc.201800807
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19400 0.8% 2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6hld
no rotation
Molmil generated image of 6hld
rotated about x axis by 90°
Molmil generated image of 6hld
rotated about y axis by 90°
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan