6HLB

X-ray structure of furin in complex with the cyclic peptide c[succinyl-Phe-2-Nal-(Arg)4-Lys]-Arg-4-Amba

Summary for 6HLB

• Entry DOI: 10.2210/pdb6hlb/pdb
• Descriptor: Furin, PHE-(ALN)-ARG-ARG-ARG-ARG-SLL-ARG-00S, CALCIUM ION, ... (8 entities in total)
• Functional Keywords: protease proprotein convertase inhibitor complex cyclic peptide, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 54389.15

Authors

Dahms, S.O. (deposition date: 2018-09-11, release date: 2019-02-06, Last modification date: 2024-01-24)

• Primary citation: Van Lam van, T.,Ivanova, T.,Hardes, K.,Heindl, M.R.,Morty, R.E.,Bottcher-Friebertshauser, E.,Lindberg, I.,Than, M.E.,Dahms, S.O.,Steinmetzer, T.; Design, Synthesis, and Characterization of Macrocyclic Inhibitors of the Proprotein Convertase Furin.; Chemmedchem, 14:673-685, 2019; PubMed: 30680958; DOI: 10.1002/cmdc.201800807

Experimental method

X-RAY DIFFRACTION (2 Å)