6HKS

Crystal structure of the PTPN3 PDZ domain bound to the HPV16 E6 oncoprotein C-terminal peptide

Summary for 6HKS

DescriptorTyrosine-protein phosphatase non-receptor type 3, Protein E6, IODIDE ION, ... (4 entities in total)
Functional Keywordspdz domain protein tyrosine phosphatase human papillomavirus e6 oncoprotein pdz binding motif, hydrolase
Biological sourceHomo sapiens (Human)
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Total number of polymer chains12
Total molecular weight85378.2
Authors
Genera, M.,Haouz, A.,Caillet-Saguy, C. (deposition date: 2018-09-07, release date: 2019-05-22, Last modification date: 2019-05-29)
Primary citation
Genera, M.,Samson, D.,Raynal, B.,Haouz, A.,Baron, B.,Simenel, C.,Guerois, R.,Wolff, N.,Caillet-Saguy, C.
Structural and functional characterization of the PDZ domain of the human phosphatase PTPN3 and its interaction with the human papillomavirus E6 oncoprotein.
Sci Rep, 9:7438-7438, 2019
PubMed: 31092861 (PDB entries with the same primary citation)
DOI: 10.1038/s41598-019-43932-x
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.19441072073 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2477 0.4% 1.9% 1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 6hks
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Molmil generated image of 6hks
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Molmil generated image of 6hks
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More Biological unit images

Molmil generated image of 6hks
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Molmil generated image of 6hks
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Molmil generated image of 6hks
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(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (6hks.pdb6.gz [37.47 KB])
Coordinate files for Biological unit (6hks.pdb5.gz [37.09 KB])
Coordinate files for Biological unit (6hks.pdb3.gz [35.51 KB])
Coordinate files for Biological unit (6hks.pdb4.gz [35.84 KB])
Coordinate files for Biological unit (6hks.pdb2.gz [37.25 KB])
Coordinate files for Biological unit (6hks.pdb1.gz [37.75 KB])