6HJJ

Crystal structure of Aurora-A L210C catalytic domain in complex with ASDO6 ligand

Summary for 6HJJ

Entry DOI	10.2210/pdb6hjj/pdb
Descriptor	Aurora kinase A, ~{N}-[4-(4-azanyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-3-methyl-phenyl]-4-[4-fluoranyl-3-(trifluoromethyl)phenyl]-4-oxidanylidene-butanamide, CHLORIDE ION, ... (6 entities in total)
Functional Keywords	protein kinase, mitosis, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33878.89
Authors	Bayliss, R.,McIntyre, P.J. (deposition date: 2018-09-04, release date: 2018-10-03, Last modification date: 2018-10-31)
Primary citation	Ocasio, C.A.,Warkentin, A.A.,McIntyre, P.J.,Barkovich, K.J.,Vesely, C.,Spencer, J.,Shokat, K.M.,Bayliss, R. Type II Kinase Inhibitors Targeting Cys-Gatekeeper Kinases Display Orthogonality with Wild Type and Ala/Gly-Gatekeeper Kinases. ACS Chem. Biol., 13:2956-2965, 2018 Cited by PubMed: 30239186 DOI: 10.1021/acschembio.8b00592 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.13 Å)

Structure validation