6HIA

The ATAD2 bromodomain in complex with compound 13

Summary for 6HIA

DescriptorATPase family AAA domain-containing protein 2, (2~{R})-~{N}-[5-(5-azanylpyridin-3-yl)-4-ethanoyl-1,3-thiazol-2-yl]-2-carbamimidamido-propanamide, SULFATE ION, ... (4 entities in total)
Functional Keywordsbromodomain, atad2, inhibitor, complex, cytosolic protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight15896.97
Authors
Sledz, P.,Caflisch, A. (deposition date: 2018-08-29, release date: 2019-02-20)
Primary citation
Dolbois, A.
Hitting a moving target: simulations and crystallography study of ATAD2 bromodomain blockers
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.897 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.23150 0.8% 3.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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