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6HHG

Crystal Structure of AKT1 in Complex with Covalent-Allosteric AKT Inhibitor 27

Summary for 6HHG
Entry DOI10.2210/pdb6hhg/pdb
DescriptorRAC-alpha serine/threonine-protein kinase, ~{N}-[2-chloranyl-5-[[1-[[4-(5-oxidanylidene-3-phenyl-6~{H}-1,6-naphthyridin-2-yl)phenyl]methyl]piperidin-4-yl]carbamoylamino]phenyl]propanamide (3 entities in total)
Functional Keywordsakt1, covalent-allosteric, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight52381.19
Authors
Landel, I.,Weisner, J.,Mueller, M.P.,Scheinpflug, R.,Rauh, D. (deposition date: 2018-08-28, release date: 2019-02-20, Last modification date: 2024-01-17)
Primary citationUhlenbrock, N.,Smith, S.,Weisner, J.,Landel, I.,Lindemann, M.,Le, T.A.,Hardick, J.,Gontla, R.,Scheinpflug, R.,Czodrowski, P.,Janning, P.,Depta, L.,Quambusch, L.,Muller, M.P.,Engels, B.,Rauh, D.
Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.
Chem Sci, 10:3573-3585, 2019
Cited by
PubMed: 30996949
DOI: 10.1039/c8sc05212c
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

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