6H4G

Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site

Summary for 6H4G

• Entry DOI: 10.2210/pdb6h4g/pdb
• Related: 6FLO
• Descriptor: Protein kinase A regulatory subunit, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, ... (4 entities in total)
• Functional Keywords: protein kinase a, regulatory subunit, nucleoside-binding protein, signaling protein
• Biological source: Trypanosoma brucei brucei TREU927
• Total number of polymer chains: 2
• Total formula weight: 69960.92

Authors

Volpato Santos, Y.,Lorentzen, E.,Basquin, J.,Boshart, M. (deposition date: 2018-07-21, release date: 2019-08-14, Last modification date: 2024-04-10)

• Primary citation: Ober, V.T.,Githure, G.B.,Volpato Santos, Y.,Becker, S.,Moya Munoz, G.,Basquin, J.,Schwede, F.,Lorentzen, E.,Boshart, M.; Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.; Elife, 12:-, 2024; PubMed: 38517938; DOI: 10.7554/eLife.91040

Experimental method

X-RAY DIFFRACTION (2.14351698698 Å)