6H4A

Human MALT1(329-728) in complex with MLT-748

Summary for 6H4A

Entry DOI	10.2210/pdb6h4a/pdb
Descriptor	Mucosa-associated lymphoid tissue lymphoma translocation protein 1, 1-[2-chloranyl-7-[(1~{R},2~{R})-1,2-dimethoxypropyl]pyrazolo[1,5-a]pyrimidin-6-yl]-3-[5-chloranyl-6-(1,2,3-triazol-2-yl)pyridin-3-yl]urea (3 entities in total)
Functional Keywords	dimer, exosite binder, hydrolase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	46171.70
Authors	Renatus, M.,Renatus, M. (deposition date: 2018-07-20, release date: 2019-02-13, Last modification date: 2024-01-17)
Primary citation	Quancard, J.,Klein, T.,Fung, S.Y.,Renatus, M.,Hughes, N.,Israel, L.,Priatel, J.J.,Kang, S.,Blank, M.A.,Viner, R.I.,Blank, J.,Schlapbach, A.,Erbel, P.,Kizhakkedathu, J.,Villard, F.,Hersperger, R.,Turvey, S.E.,Eder, J.,Bornancin, F.,Overall, C.M. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat. Chem. Biol., 15:304-313, 2019 Cited by PubMed: 30692685 DOI: 10.1038/s41589-018-0222-1 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation