6H47

Human KRAS in complex with darpin K19

Summary for 6H47

DescriptorGTPase KRas, darpin K19, SULFATE ION, ... (4 entities in total)
Functional Keywordsgtp-ase, darpin, kras signalling, signaling protein
Biological sourceHomo sapiens (Human)
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Total number of polymer chains2
Total molecular weight39158.93
Authors
Primary citation
Bery, N.,Legg, S.,Debreczeni, J.E.,Breed, J.,Embrey, K.,Stubbs, C.,Kolasinska-Zwierz, P.,Barrett, N.,Marwood, R.,Watson, J.,Tart, J.,Overman, R.,Miller, A.,Phillips, C.,Minter, R.,Rabbitts, T.H.
KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.21610 0.4% 4.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

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