6H46

Human KRAS in complex with darpin K13

Summary for 6H46

Entry DOI	10.2210/pdb6h46/pdb
Descriptor	GTPase KRas, darpin K13, GUANOSINE-5'-DIPHOSPHATE, ... (5 entities in total)
Functional Keywords	gtp-ase, darpin, kras signalling, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	36676.03
Authors	Debreczeni, J.E.,Bery, N.,Legg, S.,Breed, J.,Embrey, K.,Stubbs, C.,Kolasinska-Zwierz, P.,Barrett, N.,Marwood, R.,Watson, J.,Tart, J.,Overman, R.,Miller, A.,Phillips, C.,Minter, R.,Rabbitts, T.H. (deposition date: 2018-07-20, release date: 2019-04-24, Last modification date: 2019-06-26)
Primary citation	Bery, N.,Legg, S.,Debreczeni, J.,Breed, J.,Embrey, K.,Stubbs, C.,Kolasinska-Zwierz, P.,Barrett, N.,Marwood, R.,Watson, J.,Tart, J.,Overman, R.,Miller, A.,Phillips, C.,Minter, R.,Rabbitts, T.H. KRAS-specific inhibition using a DARPin binding to a site in the allosteric lobe. Nat Commun, 10:2607-2607, 2019 Cited by PubMed: 31197133 DOI: 10.1038/s41467-019-10419-2 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.22 Å)

Structure validation