6H3Q

Crystal structure of human carbonic anhydrase II in complex with the 4-(5-(chloromethyl)-1,3-selenazol-2-yl)benzenesulfonamide

Summary for 6H3Q

Entry DOI	10.2210/pdb6h3q/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, 4-[5-(chloromethyl)-1,3-selenazol-2-yl]benzenesulfonamide, ... (4 entities in total)
Functional Keywords	lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29690.14
Authors	Ferraroni, M.,Angeli, A.,Supuran, C. (deposition date: 2018-07-19, release date: 2019-07-17, Last modification date: 2024-01-17)
Primary citation	Angeli, A.,Trallori, E.,Ferraroni, M.,Di Cesare Mannelli, L.,Ghelardini, C.,Supuran, C.T. Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity. Eur.J.Med.Chem., 157:1214-1222, 2018 Cited by PubMed: 30193219 DOI: 10.1016/j.ejmech.2018.08.096 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.31 Å)

Structure validation