6H36

The crystal structure of human carbonic anhydrase VII in complex with 4-(4-phenylpiperidine-1-carbonyl)benzenesulfonamide.

Summary for 6H36

Entry DOI	10.2210/pdb6h36/pdb
Related	6H2Z 6H33 6H34
Descriptor	Carbonic anhydrase 7, ZINC ION, 4-(4-phenylpiperidin-1-yl)carbonylbenzenesulfonamide, ... (4 entities in total)
Functional Keywords	protein-inhibitor binding, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	31335.53
Authors	Buemi, M.R.,Di Fiore, A.,De Luca, L.,Ferro, S.,Mancuso, F.,Monti, S.M.,Buonanno, M.,Angeli, A.,Russo, E.,De Sarro, G.,Supuran, C.T.,De Simone, G.,Gitto, R. (deposition date: 2018-07-17, release date: 2018-12-19, Last modification date: 2024-01-17)
Primary citation	Buemi, M.R.,Di Fiore, A.,De Luca, L.,Angeli, A.,Mancuso, F.,Ferro, S.,Monti, S.M.,Buonanno, M.,Russo, E.,De Sarro, G.,De Simone, G.,Supuran, C.T.,Gitto, R. Exploring structural properties of potent human carbonic anhydrase inhibitors bearing a 4-(cycloalkylamino-1-carbonyl)benzenesulfonamide moiety. Eur J Med Chem, 163:443-452, 2018 Cited by PubMed: 30530195 DOI: 10.1016/j.ejmech.2018.11.073 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation