6H0G

Structure of the DDB1-CRBN-pomalidomide complex bound to ZNF692(ZF4)

Summary for 6H0G

• Entry DOI: 10.2210/pdb6h0g/pdb
• Related: 6H0F
• Descriptor: DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1,DDB1 (DNA damage binding protein 1),DNA damage-binding protein 1,DNA damage-binding protein 1,DNA damage-binding protein 1, Protein cereblon, Zinc finger protein 692, ... (5 entities in total)
• Functional Keywords: e3 ubiquitin ligase, drug mediated protein-interaction, targeted protein degradation, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 297347.78

Authors

Bunker, R.D.,Petzold, G.,Thoma, N.H. (deposition date: 2018-07-09, release date: 2018-11-07, Last modification date: 2024-01-17)

• Primary citation: Sievers, Q.L.,Petzold, G.,Bunker, R.D.,Renneville, A.,Slabicki, M.,Liddicoat, B.J.,Abdulrahman, W.,Mikkelsen, T.,Ebert, B.L.,Thoma, N.H.; Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN.; Science, 362:-, 2018; PubMed: 30385546; DOI: 10.1126/science.aat0572

Experimental method

X-RAY DIFFRACTION (4.25 Å)