6GTX

Crystal structure of the FimH lectin domain from E.coli K12 in complex with the dimannoside Man(alpha1-2)Man

Summary for 6GTX

Entry DOI	10.2210/pdb6gtx/pdb
Descriptor	Type 1 fimbrin D-mannose specific adhesin, alpha-D-mannopyranose-(1-2)-methyl alpha-D-mannopyranoside, SULFATE ION, ... (4 entities in total)
Functional Keywords	type i pilus, catch-bond, cell adhesion, lectin, upec, infection, mannose
Biological source	Escherichia coli (strain K12)
Total number of polymer chains	4
Total formula weight	69284.73
Authors	Jakob, R.P.,Sauer, M.M.,Luber, T.,Canonica, F.,Navarra, G.,Ernst, B.,Unverzagt, C.,Maier, T.,Glockshuber, R. (deposition date: 2018-06-19, release date: 2019-01-16, Last modification date: 2024-01-17)
Primary citation	Sauer, M.M.,Jakob, R.P.,Luber, T.,Canonica, F.,Navarra, G.,Ernst, B.,Unverzagt, C.,Maier, T.,Glockshuber, R. Binding of the Bacterial Adhesin FimH to Its Natural, Multivalent High-Mannose Type Glycan Targets. J.Am.Chem.Soc., 141:936-944, 2019 Cited by PubMed: 30543411 DOI: 10.1021/jacs.8b10736 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation