6GT3

Crystal Structure of the A2A-StaR2-bRIL562 in complex with AZD4635 at 2.0A resolution

Summary for 6GT3

• Entry DOI: 10.2210/pdb6gt3/pdb
• Descriptor: Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, SODIUM ION, 6-(2-chloranyl-6-methyl-pyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine, ... (7 entities in total)
• Functional Keywords: 7tm, gpcr, signalling protein, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 1
• Total formula weight: 57297.75

Authors

Borodovsky, A.,Wang, Y.,Deng, N.,Ye, M.,Stephen, T.L.,Goodwin, K.,Goodwin, R.,Strittmatter, N.,Shaw, J.,Sachsenmeier, K.,Clarke, J.D.,Hay, C.,Reimer, C.,Andrews, S.P.,Brown, G.A.,Congreve, M.,Cheng, R.K.Y.,Dore, A.S.,Mason, J.S.,Marshall, F.H.,Weir, M.P.,Lyne, P.,Woessner, R. (deposition date: 2018-06-15, release date: 2019-06-26, Last modification date: 2024-01-17)

• Primary citation: Borodovsky, A.,Barbon, C.M.,Wang, Y.,Ye, M.,Prickett, L.,Chandra, D.,Shaw, J.,Deng, N.,Sachsenmeier, K.,Clarke, J.D.,Linghu, B.,Brown, G.A.,Brown, J.,Congreve, M.,Cheng, R.K.Y.,Dore, A.S.,Hurrell, E.,Shao, W.,Woessner, R.,Reimer, C.,Drew, L.,Fawell, S.,Schuller, A.G.,Mele, D.A.; Small molecule AZD4635 inhibitor of A2AR signaling rescues immune cell function including CD103+ dendritic cells enhancing anti-tumor immunity; J Immunother Cancer, 2020

Experimental method

X-RAY DIFFRACTION (2 Å)