6GRZ

Crystal structure of the light chain dimer mH6

Summary for 6GRZ

Related5MUD
DescriptormH6, GLYCEROL (3 entities in total)
Functional Keywordslight chain dimer, light chain amyloidosis, immunoglobulin fold, protein aggregation, immune system
Biological sourceHomo sapiens
Total number of polymer chains2
Total molecular weight46129.07
Authors
Maritan, M.,Ricagno, S.,Ambrosetti, A.,Oberti, L. (deposition date: 2018-06-13, release date: 2019-06-12)
Primary citation
Maritan, M.,Ambrosetti, A.,Oberti, L.,Russo, R.,Sormanni, P.,Romeo, M.,Diomede, L.,Rognoni, P.,Lavatelli, F.,Bolognesi, M.,Ricagno, S.,Barbiroli, A.,Merlini, G.
modulating the toxic behaviour of a amyloidogenic light chain dimer through point mutations
To Be Published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24630 2.2% 3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution