6GKH

CryoEM structure of the MDA5-dsRNA filament in complex with ADP-AlF4

Summary for 6GKH

• Entry DOI: 10.2210/pdb6gkh/pdb
• Related: 6G19 6G1S 6G1X 6GJZ
• EMDB information: 0012 0023 4338 4340 4341
• Descriptor: Interferon-induced helicase C domain-containing protein 1, RNA (5'-R(P*GP*UP*CP*AP*AP*GP*CP*CP*GP*AP*GP*GP*AP*GP*A)-3'), RNA (5'-R(P*UP*CP*UP*CP*CP*UP*CP*GP*GP*CP*UP*UP*GP*AP*C)-3'), ... (7 entities in total)
• Functional Keywords: protein-rna complex, helical filament, atpase, innate immune receptor, immune system
• Biological source: Mus musculus (Mouse); More
• Total number of polymer chains: 3
• Total formula weight: 124410.17

Authors

Yu, Q.,Qu, K.,Modis, Y. (deposition date: 2018-05-21, release date: 2018-11-21, Last modification date: 2020-11-18)

• Primary citation: Yu, Q.,Qu, K.,Modis, Y.; Cryo-EM Structures of MDA5-dsRNA Filaments at Different Stages of ATP Hydrolysis.; Mol. Cell, 72:999-1012.e6, 2018; PubMed: 30449722; DOI: 10.1016/j.molcel.2018.10.012

Experimental method

ELECTRON MICROSCOPY (4.06 Å)