6GJQ

human NBD1 of CFTR in complex with nanobody T27

6GJQ の概要

分子名称Cystic fibrosis transmembrane conductance regulator, Nanobody T27, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
機能のキーワードcystic fibrosis, cftr, nanobodies, thermal stabilization, conformational dynamics, hydrolase
由来する生物種Homo sapiens (Human)
詳細
ポリマー鎖数8
分子量合計182548.25
構造登録者
主引用文献
Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C.
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10:2636-2636, 2019
PubMed: 31201318 (主引用文献が同じPDBエントリー)
DOI: 10.1038/s41467-019-10714-y
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.49 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24760 0.5% 0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード