6GJQ

human NBD1 of CFTR in complex with nanobody T27

6GJQ の概要

• エントリーDOI: 10.2210/pdb6gjq/pdb
• 分子名称: Cystic fibrosis transmembrane conductance regulator, Nanobody T27, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: cystic fibrosis, cftr, nanobodies, thermal stabilization, conformational dynamics, hydrolase
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 182548.25

構造登録者

Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C. (登録日: 2018-05-16, 公開日: 2019-06-19, 最終更新日: 2019-08-21)

• 主引用文献: Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C.; Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.; Nat Commun, 10:2636-2636, 2019; PubMed: 31201318; DOI: 10.1038/s41467-019-10714-y

実験手法

X-RAY DIFFRACTION (2.49 Å)