6GJQ

human NBD1 of CFTR in complex with nanobody T27

Summary for 6GJQ

DescriptorCystic fibrosis transmembrane conductance regulator, Nanobody T27, ADENOSINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywordscystic fibrosis, cftr, nanobodies, thermal stabilization, conformational dynamics, hydrolase
Biological sourceHomo sapiens (Human)
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Total number of polymer chains8
Total molecular weight182548.25
Authors
Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C. (deposition date: 2018-05-16, release date: 2019-06-19, Last modification date: 2019-06-26)
Primary citation
Sigoillot, M.,Overtus, M.,Grodecka, M.,Scholl, D.,Garcia-Pino, A.,Laeremans, T.,He, L.,Pardon, E.,Hildebrandt, E.,Urbatsch, I.,Steyaert, J.,Riordan, J.R.,Govaerts, C.
Domain-interface dynamics of CFTR revealed by stabilizing nanobodies.
Nat Commun, 10:2636-2636, 2019
PubMed: 31201318 (PDB entries with the same primary citation)
DOI: 10.1038/s41467-019-10714-y
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.49 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24760 0.5% 0.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution