6GHV

Structure of a DC-SIGN CRD in complex with high affinity glycomimetic.

Summary for 6GHV

Entry DOI	10.2210/pdb6ghv/pdb
Descriptor	CD209 antigen, [1-[(2~{S},3~{S},4~{R},5~{S},6~{R})-2-[(1~{S},2~{S},4~{S},5~{S})-2-(2-chloroethyloxy)-4,5-bis[[4-(hydroxymethyl)phenyl]methylcarbamoyl]cyclohexyl]oxy-6-(hydroxymethyl)-4,5-bis(oxidanyl)oxan-3-yl]-1,2,3-triazol-4-yl]methylazanium, CALCIUM ION, ... (5 entities in total)
Functional Keywords	dc-sign, inhibitor, sugar binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	6
Total formula weight	112186.70
Authors	Thepaut, M.,Achilli, S.,Medve, L.,Bernardi, A.,Fieschi, F. (deposition date: 2018-05-09, release date: 2019-09-11, Last modification date: 2024-01-17)
Primary citation	Medve, L.,Achilli, S.,Guzman-Caldentey, J.,Thepaut, M.,Senaldi, L.,Le Roy, A.,Sattin, S.,Ebel, C.,Vives, C.,Martin-Santamaria, S.,Bernardi, A.,Fieschi, F. Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis. Chemistry, 25:14659-14668, 2019 Cited by PubMed: 31469191 DOI: 10.1002/chem.201903391 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation