6GGH

Human jak1 kinase domain in complex with inhibitor

Summary for 6GGH

• Entry DOI: 10.2210/pdb6ggh/pdb
• Descriptor: Tyrosine-protein kinase JAK1, ~{N}-[5-methyl-4-[7-[[(2~{R})-2-(4-methylpiperazin-1-yl)propanoyl]amino]-1~{H}-indol-3-yl]pyrimidin-2-yl]cyclopropanecarboxamide (3 entities in total)
• Functional Keywords: janus kinase 1 kinase domain (jak1), transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 68361.98

Authors

Read, J.A.,Augustin, M.,Lammens, A. (deposition date: 2018-05-03, release date: 2019-05-22, Last modification date: 2024-01-17)

• Primary citation: Nilsson, M.; Inhibition of local lung inflammation by a potent and selective JAK1 inhibitor; activation of JAK1, but not JAK3, is critical to IL-4R mediated immune cell signalling; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.7 Å)