6GGC

p53 cancer mutant Y220C in complex with small-molecule stabilizer PK9320

Summary for 6GGC

Entry DOI	10.2210/pdb6ggc/pdb
Descriptor	Cellular tumor antigen p53, ZINC ION, [9-ethyl-7-(furan-2-yl)carbazol-3-yl]methyl-methyl-azanium, ... (6 entities in total)
Functional Keywords	p53, transcription factor, tumor supressor, cancer therapy, oncogenic mutant, protein misfolding, small-molecule stabilizer, molecular chaperone, dna binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	50019.46
Authors	Joerger, A.C. (deposition date: 2018-05-03, release date: 2019-05-22, Last modification date: 2024-01-17)
Primary citation	Bauer, M.R.,Jones, R.N.,Tareque, R.K.,Springett, B.,Dingler, F.A.,Verduci, L.,Patel, K.J.,Fersht, A.R.,Joerger, A.C.,Spencer, J. A structure-guided molecular chaperone approach for restoring the transcriptional activity of the p53 cancer mutant Y220C. Future Med Chem, 11:2491-2504, 2019 Cited by PubMed: 31633398 DOI: 10.4155/fmc-2019-0181 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.24 Å)

Structure validation