6GCU

MET receptor in complex with InlB internalin domain and DARPin A3A

Summary for 6GCU

Entry DOI	10.2210/pdb6gcu/pdb
Descriptor	Hepatocyte growth factor receptor, Internalin B, DARPin A3A (3 entities in total)
Functional Keywords	receptor tyrosine kinase, bacterial invasion protein, artificial binding protein, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	6
Total formula weight	265413.05
Authors	Meyer, T.,Andres, F.,Iamele, L.,Gherardi, E.,Pluckthun, A.,Niemann, H.H. (deposition date: 2018-04-19, release date: 2019-05-15, Last modification date: 2024-01-17)
Primary citation	Andres, F.,Iamele, L.,Meyer, T.,Stuber, J.C.,Kast, F.,Gherardi, E.,Niemann, H.H.,Pluckthun, A. Inhibition of the MET Kinase Activity and Cell Growth in MET-Addicted Cancer Cells by Bi-Paratopic Linking. J.Mol.Biol., 431:2020-2039, 2019 Cited by PubMed: 30930049 DOI: 10.1016/j.jmb.2019.03.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (6.001 Å)

Structure validation