Solution structure of FUS-RRM bound to stem-loop RNA

Summary for 6GBM

DescriptorRNA-binding protein FUS, RNA (5'-R(*GP*GP*CP*AP*GP*AP*UP*UP*AP*CP*AP*AP*UP*UP*CP*UP*AP*UP*UP*UP*GP*CP*C)-3') (2 entities in total)
Functional Keywordsrna, rna recognition motif, rrm, rna binding protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight18575.86
Loughlin, F.E.,Allain, F.H.-T. (deposition date: 2018-04-15, release date: 2019-02-20)
Primary citation
Loughlin, F.E.,Lukavsky, P.J.,Kazeeva, T.,Reber, S.,Hock, E.M.,Colombo, M.,Von Schroetter, C.,Pauli, P.,Clery, A.,Muhlemann, O.,Polymenidou, M.,Ruepp, M.D.,Allain, F.H.
The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.
Mol. Cell, 73:490-504.e6, 2019
PubMed: 30581145 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2018.11.012
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone20 2.5% 0.59MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures

More Asymmetric unit images

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