6G7A

Crystal structure of human carbonic anhydrase isozyme XII 2-(benzylamino)-4-chloro-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide

Summary for 6G7A

Entry DOI	10.2210/pdb6g7a/pdb
Related	6G5L 6G5U 6G6T
Descriptor	Carbonic anhydrase 12, ZINC ION, 1,2-ETHANEDIOL, ... (5 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	122211.12
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2018-04-05, release date: 2019-03-13, Last modification date: 2024-01-17)
Primary citation	Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Kisonaite, M.,Smirnov, A.,Manakova, E.,Grazulis, S.,Matulis, D. Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem, 156:61-78, 2018 Cited by PubMed: 30006175 DOI: 10.1016/j.ejmech.2018.06.059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation