6G5U

Crystal structure of human carbonic anhydrase isozyme XIII with N-butyl-2,4-dichloro-5-sulfamoyl-benzamide

Summary for 6G5U

Entry DOI	10.2210/pdb6g5u/pdb
Descriptor	Carbonic anhydrase 13, ZINC ION, ~{N}-butyl-2,4-bis(chloranyl)-5-sulfamoyl-benzamide, ... (6 entities in total)
Functional Keywords	drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	60386.20
Authors	Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2018-03-30, release date: 2019-03-13, Last modification date: 2024-01-17)
Primary citation	Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Kisonaite, M.,Smirnov, A.,Manakova, E.,Grazulis, S.,Matulis, D. Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem, 156:61-78, 2018 Cited by PubMed: 30006175 DOI: 10.1016/j.ejmech.2018.06.059 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation