6G5L
Crystal structure of human carbonic anhydrase isozyme XII with 4-chloro-2-(cyclohexylamino)-N-(2-hydroxyethyl)-5-sulfamoyl-benzamide
Summary for 6G5L
Entry DOI | 10.2210/pdb6g5l/pdb |
Descriptor | Carbonic anhydrase 12, ZINC ION, 4-chloranyl-2-(cyclohexylamino)-~{N}-(2-hydroxyethyl)-5-sulfamoyl-benzamide, ... (6 entities in total) |
Functional Keywords | drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor comple, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 4 |
Total formula weight | 122391.45 |
Authors | Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2018-03-29, release date: 2019-03-13, Last modification date: 2024-01-17) |
Primary citation | Zaksauskas, A.,Capkauskaite, E.,Jezepcikas, L.,Linkuviene, V.,Kisonaite, M.,Smirnov, A.,Manakova, E.,Grazulis, S.,Matulis, D. Design of two-tail compounds with rotationally fixed benzenesulfonamide ring as inhibitors of carbonic anhydrases. Eur J Med Chem, 156:61-78, 2018 Cited by PubMed: 30006175DOI: 10.1016/j.ejmech.2018.06.059 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.21 Å) |
Structure validation
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